Hello World!
If your cat received a Solensia® injection(s) – or if you just want to share your thoughts on this new medication, please send your comments to yourpetsfriend@gmail.com and I will add them to this page. It is always nice to know your cat’s name and the region of the world where you and your cat reside. RSH Your comment in black, Owner updates in green My comments in purple Scientist’s Comments in maroon
On Wed, Aug 3, 2022 at 10:21 AM B.L wrote:
Hi, My sweet cat’s name is Lilly. She is 16 years old and has significant arthritic pain. She is a trooper and still climbs on things but is VERY sensitive if anyone pets her on her backside, closer to her tail. She is scheduled for her first injection in 2 weeks. I’m nervous about potential side effects – from anaphylaxis to uncomfortable itching and fur loss. She has had kidney insufficiency. (she is also hyperthyroid) I understand the studies were only based on 3 months of the medication. What if it exacerbates her kidney disease? I’m really interested to know how other cats have tolerated this medication and if it helped them. I plan to update this after she received her first injection – if I go through with it. Hope some people write in with their experiences soon and hope this medication helps all of our fur babies.
Michigan, USA
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On Tuesday, Aug 9, 2022 at 3:34 PM E.M wrote:
Dear Dr. Hines, I am not an expert in the field of Nerve Growth Factor and pain. But I am aware that anti-NGF therapies might have beneficial effects in pain management. Increased concentrations of NGF have been reported in chronic pain conditions such as interstitial cystitis, prostatitis, arthritis, pancreatitis, chronic headaches, cancer pain, diabetic neuropathy, and non-cancer pain. Several early clinical trial have not reported consistent efficacy for anti-NGF drugs in treating pain. However, as you pointed out, Solensia, an anti-NGF monoclonal antibody therapy, has been approved to control feline OA pain. I am not aware of studies investigating the effect of this drug on brain function. So one can only speculate what the effects of lowering NGF level might have on brain function in cats. In primate, rodents and human, a lack of NGF or alterations to it cognate receptors (p75NTR and TrkA) result in cognitive decline in the aged and Alzheimer’s disease brain. Reducing NGF in brain will also have a deleterious effect upon the cholinergic neuron basal forebrain cortical projection system that is dependent upon NGF for its survival. Decrements in NGF would likely activate a cascade of events leading to either cell death in the brain, not to mention the possibility of the formation of brain lesions (plaques and tangles) and long-term alterations to inflammatory mediators within the central and peripheral nervous systems. Since the trigeminal system expresses the NGF low-affinity p75 receptor, reducing NGF may result in unwanted actions. There may be unexpected actions that are specific to the age of the cat and its medical history.
Take care, E.
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